VANTAS®
This product information is intended for U.S. residents only.
VANTAS® (histrelin implant) is a soft and flexible 12-month hydrogel
implant that provides histrelin, a luteinizing hormone-releasing hormone (LHRH)
agonist, for the palliative treatment of advanced prostate cancer. The product utilizes
the Company’s patented HYDRON® Polymer Technology that allows for
a controlled delivery of medicine over a 12-month period.
LHRH agonist therapy is the current standard of care for the palliative treatment
of advanced prostate cancer by suppressing the production of testosterone. Testosterone
is believed to promote the growth of tumors associated with prostate cancer. Histrelin,
the active medicine in VANTAS, is a potent LHRH agonist and a powerful inhibitor
of testosterone production. VANTAS is presently the only once- yearly histrelin
therapy indicated for the palliative treatment of advanced prostate cancer.
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www.vantasimplant.com to learn more
- VANTAS® is indicated in the palliative treatment of advanced prostate
cancer.
- Important Safety Information
- Do not use VANTAS if you are allergic to the medicine histrelin or other medicines
called gonadotropin releasing hormone (GnRH) agonists, are a woman or are a child
under 18 years of age.
- Before using VANTAS, tell your doctor about all the medicines you take, including
prescription and nonprescription medicines, vitamins, and herbal supplements.
- VANTAS is placed under the skin of your upper arm. Your doctor will numb your arm,
make a small cut (incision), and place VANTAS under the skin. The cut will be closed
with stitches and special surgical tape and covered with a bandage. Keep your arm
clean and dry for 24 hours. Your doctor will give you complete instructions. You
may have some pain, bruising, and redness at the insertion site during and after
VANTAS is inserted and removed. These usually go away without treatment within 2
weeks.
- Your doctor will do blood tests to check on your response to treatment with VANTAS.
For example, your doctor may check your prostate specific antigen (PSA) or testosterone
levels.
- The most common side effects of VANTAS are hot flashes, tiredness, skin reactions
at the implant site, testicles become smaller, urination problems, breasts become
larger, erectile dysfunction (impotence), and constipation.
- VANTAS can cause an increase in testosterone during the first week after it is implanted.
Your symptoms may get worse during the first few weeks of treatment or you may get
new symptoms. Call your doctor right away if you get new or worse bone pain, weakness
or lose feeling in your legs, have blood in your urine, or you have trouble urinating
or cannot urinate.
- These are not all of the side effects of VANTAS. For more information, ask your
doctor or pharmacist.
- VANTAS can be expelled from your body through the original incision site. This occurs
infrequently. Remember to see your doctor for routine checks on your condition to
ensure that VANTAS is present and functioning in your body.
- If you would like more information, talk with your doctor. You can ask your doctor
or pharmacist for information about VANTAS that is written for health professionals.
More information about VANTAS is available on the internet at www.VANTASIMPLANT.com.
- Please see the accompanying Full Prescribing Information
for VANTAS.
VANTAS® is a registered trademark of Endo Pharmaceuticals
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